As a deubiquitinating enzyme (DUB), the physiological substrates of ataxin-3 (ATX-3) remain elusive, which limits our understanding of its normal cellular function and that of pathogenic mechanism of spinocerebellar ataxia type 3 (SCA3).Here, we identify p53 to be a novel substrate of ATX-3.ATX-3 binds to native and polyubiquitinated p53 and deubiq
Drilling fluid loss in depleted reservoir has been an import issue faced by further tapping the potential of old oil fields.Accurate evaluation of the fracture pressure is the foundation to avoid mud loss.Traditional views suggest that tensile failure is the only fracture mode and the fracture pressure should be determined by a tensile failure crit
Background Pre-existing Jills cardiovascular disease (CVD) or cardiovascular risk factors have been associated with an increased risk of complications following hospitalisation with COVID-19, but their impact on the rate of recovery following discharge is not known.Objectives To determine whether the rate of patient-perceived recovery following hos
Highly unsaturated soil mixtures (clay, sand and gravel) are used as building materials in many parts of the world, and there is increasing interest in understanding their mechanical and hydraulic behaviour.In the laboratory, x-ray computed tomography (XRCT) is becoming more widely used to investigate the microstructures of soils, however a crucial
Objectives: It is important to understand the unique perspectives and values that motivate patients and clinicians in rural primary care settings to participate in clinical care activities.Our objective was to explore perspectives, preferences, and values related to primary care that could influence implementation of evidence-based programs.Methods